Problems: Cost and time to test all 16 people!
Instead of testing each individual, observations are made on groups of individuals pooled together with group size s > 1. In medical-screening experiments involving infectious diseases, grouping might involve pooling blood samples from several individuals to test for seropositivity. In most applications, the group response is binary, classified as either positive or negative.
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Problems: Cost and time to test all 16 people!
If the group tests negative, then all 16 individuals are declared negative. Thus, it took just one test to determine 16 people are negative; it would have taken 16 tests with individual testing to come to this same conclusion. If the group tests positive, then at least one of the 16 individuals is a positive. Various retesting strategies can be implemented to determine who is positive. Note that the American Red Cross screens blood donations in groups of size 16.
